Summer Research Celebration 2014
Thursday, September 11, 2014
3:30 - 4:15 Winter Hall - Poster Display and Reception in the Rotunda
4:15 - 5:00 Talks to be held in Darling Foundation Lecture Hall
Researchers have worked over the summer in the fields of Biology, Chemistry, Physics,and Psychology The following abstracts detail their work and collaboration with faculty members. Faculty, students, parents, alumni and prospective students are invited to attend. Please RSVP to Barb Kennedy in the Provost's Office at email@example.com
The Role of Tau Protein Oligomerization in Neurodegenerative Disease
Tau protein is an essential microtubule-associated protein that provides support to the nervous system. In some cases, the natively unfolded tau forms abnormal fibrillar deposits in the brain and causes neurodegenerative disease. Recent research suggests that oligomers of tau may be more toxic than fibrils. A 39-mer fragment was chosen to investigate the oligomerization potential in a region of tau. The peptide was synthesized by solid phase peptide synthesis. Mass spectral data revealed a significant amount of oxidized product. The reduction and purification of the peptide will be discussed. The purified peptide has been studied using electron microscopy and circular dichroism. Nicolette Dressler '15 and Kristi Lazar Cantrell, Assistant Professor of Chemistry.